Twenty years after a fungal outbreak ravages the planet, survivors Joel and Tess are tasked with a mission that could change everything.

In 2003, an Indonesian scientist makes a devastating discovery. In 2023, now outside of the quarantine zone, Joel and Tess clash over Ellie's fate as they navigate a long-abandoned Boston overrun with Infected.

Doomsday prepper Bill prepares to ride out the apocalypse alone ... until a mysterious stranger upends his plans. Years later, Joel and Ellie seek Bill's guidance -- and find themselves at a crossroads.

After a harrowing trek across a desolate United States, Joel and Ellie find themselves navigating dangerous Kansas City on foot. Later, rebel leader Kathleen instigates a manhunt -- one that pits her violent civilian militia against the world's best hope.

While attempting to evade the rebels, Joel and Ellie cross paths with the most wanted man in Kansas City. Kathleen continues her hunt.

After months of travelling, Joel and Ellie receive a grave warning about what lies ahead. Later, Ellie learns more about Joel's past -- while Joel tries his best to forget.

As Joel fights to survive, Ellie's struggle to save him stirs memories of her life in a FEDRA orphanage. Weeks before meeting Joel, Ellie recalls joining her best friend Riley for a night to remember ... one that will change the fate of the world forever.

After crossing paths with a vengeful group of survivors, Ellie's fighting spirit draws unwanted attention from its leader. Still battling for his life, a weakened Joel faces off with a hunting party out for blood.

After being pursued by Infected, a pregnant Anna places her trust in a lifelong friend. Years later, Ellie is forced to grapple with the emotional toll of her journey, while Joel faces a devastating decision of his own.